By Carl-Fredrik Mandenius
During this professional instruction manual either the subjects and individuals are chosen in an effort to offer an authoritative view of attainable purposes for this new know-how. the result's an updated survey of present demanding situations and possibilities within the layout and operation of bioreactors for high-value items within the biomedical and chemical industries.
Combining thought and perform, the authors clarify such modern applied sciences as single-use bioreactors, bioreactor simulators, and tender sensor tracking, and talk about novel purposes, comparable to stem mobile creation, approach improvement, and multi-product reactors, utilizing case reviews from academia in addition to from undefined. a last part addresses the most recent traits, together with tradition media layout and structures biotechnology, that are anticipated to have an expanding impression on bioreactor design.
With its specialise in state of the art applied sciences and discussions of destiny advancements, this guide will stay a useful reference for a few years to come.
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Extra info for Bioreactors : design, operation and novel applications
The implementation of these data into the bioreactor and bioprocess scenarios versus the production engineering goals requires a synergistic mind-set that is not yet established in the industry. However, there are few reasons to believe that this will not happen in near future. The combination of the systems biology view with microbial and cellular physiology and how this knowledge is transduced into design practice for more eﬃcient processing is also a challenge required to be further pursued (see Chapter 8).
Still, traditional biological systems, such as microbial and cell cultures for metabolite and protein production, require the same kind of attention although this has historically been going on for a longer period. Basic principles and implementation methods for scaling up and scaling out the production systems ﬁt into production encompassing all cell types (see Chapters 4 and 11). The access to reliable analytical platforms is necessary for good design work; this may include a variety of tools and methods, such as microbioreactors (see Chapter 2), single-use reactors (see Chapter 9), scale-down methods (see Chapter 11), and bioreactors-on-a-chip (see Chapter 3).
This is, in particular, true for conceptual design methodologies. Viewpoints on bioprocess unit design, bioreactors in particular, with a conceptual mind-set have gradually unfolded in recent years. 5 Framework for the development of a new product and its production depicted from three critical hurdles: the transfer of the product concept into a bioprocess, the transcendence of development from natural science to engineering, and the interaction between screening, scale-up, and full-scale manufacture.
Bioreactors : design, operation and novel applications by Carl-Fredrik Mandenius