By Perminder Sachdev
This quantity offers the 1st accomplished account of the clinical and medical points of akathisia and comparable syndromes akin to stressed legs syndrome (RLS), other kinds of motor restlessness, and neuroleptic-induced dysphoria. the main target is on drug-induced akathisia and its a variety of subtypes. the writer explores its courting to the restlessness as a result of different neurological problems, offers a brand new synthesis of the pathophysiological mechanisms of akathisia, and offers arguments for brand spanking new operational standards for the learn prognosis of drug-induced akathisia. recommendations for the size of akathisia also are mentioned, as are remedy techniques. The e-book can be really valuable for psychiatrists, neurologists, and different physicians looking a greater realizing of those disabling syndromes.
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Extra resources for Akathisia and Restless Legs
The key elements of the model are the following: 1. The neuronal circuits involved in the pathogenesis of restlessness have complex afferent and efferent connections with large parts of the neocortex. 2. The key elements are cortical-subcortical neuronal loops that involve dopamine (DA), glutamic acid (Glu), y-aminobutyric acid (GABA) and other neurotransmitters. 3. Motor activity is increased if subcortical structures are disinhibited, possibly through a number of different processes that involve distinct pathways leading to the same goal.
Zitrin et al (1980) reported it in 20% of agoraphobic women treated initially with a 25-mg/day dosage of imipramine. Pohl et al (1988), in a systematic study of the phenomenon, reported it in 49 of 158 panic disorder patients, usually developing at The anatomy of restlessness 35 dosages less than 75 mg/day and occurring more frequently with desipramine. Interestingly, patients with bulimia nervosa and major depression who were treated with the same medication did not develop the syndrome, leading to the suggestion by the authors that it was specific to panic disorder.
Agitation also appears to have a relationship with age, although research evidence does not always support this. The agitated depressive patient usually fidgets a great deal, shifting position continually in the chair or playing with cigarettes, handbag or the fingers. In the early stages, patients are usually aware of this restlessness and may try to compensate for it. They may try to control their agitation by gripping something or holding on firmly to the arms of the chair. In such cases, the motor activity in the arms and the body may cease, but it often becomes apparent in the form of restless legs and feet.
Akathisia and Restless Legs by Perminder Sachdev