By Urs von Stockar (Editor), Luuk van der Wielen (Editor)
Approach integration has been essentially the most lively learn fields in Biochemical Engineering over the past decade and it'll stay so if bioprocessing is to develop into extra rational, effective and effective. This quantity outlines what has been completed lately. Written by means of specialists who've made vital contributions to the eu technological know-how, origin software on strategy Integration in Biochemical Engineering, the amount makes a speciality of the development made and the key possibilities, and likewise at the boundaries and the demanding situations in bioprocess integration that lie forward. the concept that of bioprocess integration is handled at numerous degrees, together with integration on the molecular, organic, bioreactor and plant degrees, but in addition accounting for the mixing of separation and mass move operations and biology, fluid dynamics and body structure, in addition to simple technological know-how and strategy know-how.
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To further improve the agreement between simulations and experimental observations, the parameters c1, CK and c3, CK in the Chen-Kim model were slightly modified. For modification of these parameters the ratio of the Eulerian macro length scale to the impeller blade height has been employed. The property can be compared in geometric similar vessels. For more details the reader is referred to the original paper by Jenne and Reuss . Table 2. 15 28 S. Schmalzriedt et al. The Reynolds equations, the continuity equation, which is turned into an equation for pressure correction , and the transport equations for the turbulence quantities k and e, are integrated over the respective finite volume elements resulting from the discretization of the stirred tank domain.
2 Modeling and Simulation of Gas-Liquid Flow in Stirred Tank Reactors It is generally now accepted that Reynolds-averaging Navier-Stokes equations and modeling the Reynolds-stresses with an appropriate turbulence model is a promising method of flow behavior modeling. Ongoing development of commercial computational fluid dynamics software (CFD) and increasing computer power are continuously improving the conditions for the simulation of the threedimensional and turbulent flow structure in stirred tanks.
24 S. Schmalzriedt et al. changing environmental conditions. This in turn may result in drastic changes in metabolism and final outcome of the process. The long-term mathematical description of these phenomena requires flexible tools to be adapted to different systems and to be able to integrate the process and reactor. Accordingly, this paper addresses these issues by discussing the following tools: (1) Application of computational fluid dynamics (CFD) for modeling and simulation of the flow behavior of the abiotic phases.
Advances in Biochemical Engineering & Biotechnology, Volume 080: Process Integration in Biochemical Engineering by Urs von Stockar (Editor), Luuk van der Wielen (Editor)