Advanced Bayesian methods for medical test accuracy - download pdf or read online

By Lyle D. Broemeling

ISBN-10: 143983878X

ISBN-13: 9781439838785

Useful in lots of components of medication and biology, Bayesian equipment are fairly beautiful instruments for the layout of medical trials and diagnostic exams, that are in line with proven details, frequently from similar past studies. Advanced Bayesian equipment for clinical try Accuracy starts off with a assessment of the standard measures akin to specificity, sensitivity, confident and unfavorable predictive worth, and the world less than the ROC curve. Then the scope expands to hide the extra complex subject matters of verification bias, diagnostic assessments with imperfect gold criteria, and people for which no top of the line is accessible.

Promoting accuracy and potency of scientific trials, exams, and the diagnostic technique, this book:

  • Enables the person to successfully observe previous details through a WinBUGS package deal
  • Presents many principles for the 1st time and is going a ways past the 2 common references
  • Integrates reader contract with diverse modalities―X-ray, CT Scanners, and more―to examine their impact on scientific attempt accuracy
  • Provides useful chapter-end problems

Useful for graduate scholars and consulting statisticians operating within the quite a few components of diagnostic medication and research layout, this sensible source introduces the basics of programming and executing insects, giving readers the instruments and adventure to effectively research experiences for clinical try accuracy.

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Additional info for Advanced Bayesian methods for medical test accuracy

Sample text

The chapter concludes by estimating accuracy with ROC areas for tests with continuous scores and comparing two tests via their ROC areas. 2 Chapter 5: Regression and medical test accuracy This chapter deals with patient covariate information that can be accounted for in the estimation of test accuracy. Regression techniques for ordinal and K11763 Chapter: 3 page: 30 date: June 17, 2011 Preview of the Book 31 continuous test scores are considered, and the chapter begins with an example from audiology, where the subject’s covariate information is accounted for in estimating the true and false positive fractions.

The two groups were similar with regard to age, gender, lesion size, and lesion location, and the major endpoints were diagnostic yield (number of diagnostic samples and test accuracy, measured by sensitivity and specificity) and frequency of pneumothorax. The pathology report served as a gold standard for test accuracy. The statistical analysis consisted of estimating the test accuracy of the two methods and comparing accuracy via the chi-square test. There was no significant difference between the two groups with regard to sensitivity and specificity, however, there were significant differences between the two with regard to complications from the procedure.

Improved sentinel lymph node localization in patients with primary melanoma with the use of radiolabeled colloid. Surgery, 124:203, 1998. E. Revised American Joint Committee on Cancer staging criteria accurately predict sentinel lymph node positivity in clinically node negative melanoma patients. Annals of Surgical Oncology, 10(5):569, 2003. E. Small (<2 cm) subpleural pulmonary lesions; short versus long needle path, CT-guided biopsy: Comparison of diagnostic yields and complications. Radiology, 234:631, 2005.

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Advanced Bayesian methods for medical test accuracy by Lyle D. Broemeling

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